Przemiana glutationu we krwi biegaczy średniodystansowych

Agnieszka Zembroń-Łacny, Kazimierz Szyszka, Barbara Sobańska, Rafał Pakuła

Streszczenie
The major factors determining the intensity of oxidative stress, which is induced by physical effort are intensity and duration of exercise and the type of performed exercise. The aim of research was define the changes in prooxidant-antioxidant equilibrium, which occurred under the influence of exercise of maximum intensity. The research included a group of 12 sportsmen AZS AWF in Gorzów Wlkp. Training middle distance race. They performed 3 min running exercise of an increasing intensity to exhaustion, which were separated by 1 min rest period. The test was performed on a treadmill, inclined at 2°. The speed of the first exercise stages was 10.3 km/h, and to the ones that followed 2 km/h were added. The physical test evoked in blood a 34% (p < 0.005) increase of the total glutathione (GSH + GSSG) with no change in concentration of the reduced form (GSH). The activity of glutathione reductase (GR) in red blood cells increased during the effort by 28% (p < 0.05). This indicates the intensification of glutathione metabolism mainly in red blood cells. In the plasma 2.6 times increase of GSH + GSSG concentration accompanied by a simultaneous 12% (p < 0.05) decrease of GR activity was noticed after exercise (30 min rest). This may indicate release of GSH from liver. No changes in the level of lipid peroxidation products in red blood cells were noticed during the exercise. The intensification of glutathione metabolism with no change in process of lipid peroxidation in the blood of the tested sportsmen indicates efficient defense against oxidative stress.

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