Establishing a basis for clenbuterol treatment of some diseases of the CNS

Andrzej Brzecki

Summary
The results of sympathetic cerebropetal blockade in an experimental osmotic and angiogenic oedema influenced by stimulants and anaesthetic factors are presented in illustrations. The results are in accordance with research in recent years, and confirm the reports concerning astrocyte significance in the role of an intermediary in the blood-brain barrier, and the sensibility of brain tissue that is connected with their neurobiological activity. Low responsiveness to stimuli of brain tissue and changes in brain microvessel permeability (e.g. in a coma), result in inhibitory stimulation (GABA-ergic).
The above, as well as other data mentioned, prove that adrenomimetic medicines work neuroprotectively and that they affect the brain´s activity which is connected with both local blood flow and neurochemical stimulation. The issue of neuroprotective factors has been explained, and the significance of adrenomimetic-clenbuterol which stimulates beta₂-adrenoreceptors of the transverse striated muscles, and protects the brain by means of brain - derived neurothropic factors (BDNF) has been emphasised. On this basis, we have put forward a hypothesis about the treatment neuro-degenerative CNS illnesses. The significance of adrenergic neurotransmitters and other stimulators of the central regulation, and some possibilities for administration of beta₂-adrenomimetics in some motor disturbances of the CNS has been discussed, and the usefulness of application of clenbuterol in cerebral palsy in children has been motivated. On this basis, clenbuterol has been used in treatment in the Rehabilitation Centre in Mikoszów near Strzelin. It has turned out that this well known long term medicine in asthma treatment of both children and adults showing practically no side effects is useful in treating children for some motor disturbances of the central nervous system, in particular various types of motor hyperexcitability, and motor paresis.

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