Studies on the effect of ozonotherapy on blood serum α-tocopherol level in patients with atherosclerotic ischemia of lower extremities

Ewa Bartkowiak-Fludra¹, *Aldona Jasińska-Stępniak¹, Marek Gogolewski¹, Irena Ponikowska²

Summary
Summary
The aim of the study was to investigate the destructive effect of ozone on blood serum vitamin E levels in patients with ischemia and macroangiopate dialutica of lower extremities. The primary form in blood serum is α-tocopherol [over 85%], the most biologically active tocochromanol. Sixteen assays were performed in two replications, in which blood serum concentration of vitamin E was determined at the beginning of therapy, after one infusion and after ozonotherapy was completed. Initial vitamin E concentration in the blood serum of patients showed varied vitamin E levels and the occurrence of hypovitaminosis. The action of ozone resulted in individualized vitamin E decomposition, in most cases lowering its level to one below its physiological blood serum content.

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