Analysis of key agents influencing therapeutic success in balance disturbances treated ambulatory by Betahistine

*Jarosław Wysocki^{1, 2}, Piotr Orszulak¹

Summary
Summary
Vertigo and dizziness are common medical problems, associated with several specialties. Management with these patients is lingering, difficult and not in every case successful. In order to find and assess possible factors influencing final therapeutic success in therapy of vertigo and balance disorders a prospective, questionnaire study in primary care units was realized. Patients (4648), adults and adolescents, both gender, suffering from vertigo or other balance disturbances were included into the study. Results of Betahistine (Histimerck(r)) application during a 30-60 days period in doses 24 or 48 mg/day was analyzed. Withdrawal of vertigo or dizziness in physical examination were undertaken as a therapeutic success. Generally results of therapy were better in patients with diagnosis of vertigo labyrhintica and in younger than in older patients. Statistically significant positive influence on therapeutic success was proved not for summaric dose of Betahistine but for summaric time of therapy and therapy according to alternative model: the different dose in the following 30 days. Head injury in the past, cervical spine degenerative changes and VIII nerve diseases deteriorated chances of headache, waving and visual disorders release but only for patients with diagnose of vertigo centralis. In patients with vertigo labyrhintica hypertension significantly deteriorated final result in headache release. It was also proved negative influence of acoustic injury on vertigo release in all the patients. We could conclude that to the group which is anticipated as having worse therapeutic effects belong older patients and patients burdened with cervical spine degenerative changes, acoustic injury and head or cervical spine injuries in the past. Extending the time of therapy until 60 days provides considerable positive effect.

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