Substytucja enzymami trzustkowymi w leczeniu schorzeń trzustki

© Borgis - Medycyna Rodzinna 3-4/2002, s. 106-109

Marta Wysocka

Summary
Severe pancreatic exocrine insufficiency lead to malabsorption of nutrients. In contrast to other key enzymes, pancreatic synthesis and secretion of lipase is impaired more rapidly, its intraluminal survival is shorter due to its luminal digestive action isn´t compensated by nonpancreatic mechanisms. As a consequence, steatorrhea is in general more severe and occurs several years before clinical malabsorption of protein or starch. Adequate nutrient absorption requires delivery of sufficient enzymatic activity into duodenal lumen simultaneously with meal nutrients. In the majority of patient, pancreatin microsphere preparation containing 25 000-40 000 units of lipase will lead to clinical improvement and reduction of steatorrhea in patients with exocrine pancreatic insufficiency.

To jest tylko fragment artykułu. Aby przeczytać całość, przejdź do Czytelni medycznej.