Klotho protein protects against aging and nicotine-induced chronic cellular stress

Daniel Piątek, Emilia Migryt, Kamila Tuzim, Joanna Szydełko, *Anna Boguszewska-Czubara

Summary
From 1997, when Klotho protein was first discovered and named “the anti-aging hormone”, scientists have been thoroughly investigating its biological properties. This protein plays an important role in numerous metabolic pathways that contribute to slower ageing processes. The prevalence of neurodegenerative diseases, impairment of cognitive functions and chronic stress increases with age. Additional factors, such as nicotine, rosiglitazone, statins, blood-pressure lowering drugs, calcitriol, magnesium, chronic psychosocial stress and aerobic exercises have an influence on Klotho protein plasma concentration. The research on proteins that increase Klotho plasma levels is important because of broad range of biological processes in which Klotho is engaged. Further studies on this substance could result in new possibilities of treatment for several common diseases.

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