Aktywność telomerazy i długość telomerów w rozrostach układu chłonnego

© Borgis - Medycyna Rodzinna 4/2004, s. 187-192

Iwona Urbanowicz, Jolanta Stacherzak-Pawlik, Mieczysław Woźniak

Summary
Telomerase is a telomere – synthesing reverse transcriptase. that can compensate for the loss of telomere associated with cell divisions. Telomerase activity has been found in the majority of cancer, but absent in the most normal cells .However telomerase activity is detectable at low levels in normal human T and B cells, increases in hematopoietic progenitor cells upon their proliferation and differentiation. Shortened telomeres and high telomerase activity almost always correlates with disease severity in lymphoproliferative disorders. Measurement of telomere length and telomerase activity might be useful to monitor disease condition. and as well prognostic marker in lymphoproliferative disorders.

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