Próby zastosowania szałwii w leczeniu zaburzeń poznawczych i choroby Alzheimera

*Zygmunt Zdrojewicz¹, Damian Pypno², Bartosz Bugaj², Krzysztof Cabała², Mateusz Waracki²

Summary
Salvia (Salvia officinalis) has been famous for its medical properties for many years. The most known species is the common salvia – a herb that has been used in the ancient Greece by figures such as Hipocrates. Other therapeutically relevant species include clary sage (Salvia sclarea), red sage (Salvia miltiorrhiza), Greek sage (Salvia triloba) and Spanish sage (Salvia lavandulaefolia).
Developing effective methods of treating neurodegenerative diseases has become one of the most important challenges in the modern, constantly aging society. Alzheimer’s disease (AD), the most common condition in this group affecting older individuals, is characterized by progressive and irreversible mental degradation that leads to dementia. Globally, the total number of people affected by AD has already reached about 24 million, but it is expected to rise even higher. Various species of salvia have been analyzed as a potential method of improving cognitive functions and preventing memory loss. Researches on murine models have shown that the rosmarinic acid and tanshinones prevent the formation of β-amyloid plaques, which are the key element in the pathogenesis of AD. Moreover, it has been proven that said substances present neuroprotective properties due to their role in the antioxidation processes.
The goal of this dissertation is to present neuroprotective properties of substances present in various salvia species. Original articles and reviews were used to summarize the results of studies referring to the topic.

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