Znaczenie złożonych schematów leczenia w jednej tabletce w wybranych dziedzinach terapeutycznych*

Marlena Broncel¹, Kamila Wójcik², Elżbieta Jabłonowska²

Summary
One of the main methods for improving adherence to therapeutic recommendations is simplification of treatment regimens or decrease of the frequency and number of medicines taken during a day. Unfortunately, in the case of most chronic illnesses, such as: arterial hypertension, coronary disease, cardiac insufficiency, HIV or HCV infection, it is not possible to reduce the number of medicines, because only using several drugs with different mechanisms of action provides high efficacy and safety of therapy. Thus the concept of a single tablet regimen (STR).
A huge progress has been made in the treatment of HIV infection. At the moment, there are many antiretroviral drugs available on the market, which limit HIV replication and progression of the disease. Typical antiretroviral regimen consists of three different drugs, which may be combined in one tablet. Single tablet regimens are as effective as other therapeutic schemes and have a favorable safety profile. In many studies, the highest adherence has been described for drugs taken once a day in the form of one tablet. According to Polish and international recommendations, compound drugs, such as Atripla, Eviplera and Stribild, belong to preferred antiretroviral regimens. Single tablet regimen administered once a day is the perfect therapeutic option in patients looking for simplified therapy.
Development of research on antiretroviral drugs contributed to currently observed revival in the treatment of HCV infection. Recently approved drugs are characterized by high efficacy and good tolerance and safety. Their mechanism of action involves direct inhibition of HCV replication. The use of the right combination of these drugs in most patients allows elimination of HCV infection without the use of pegylated interferon. At the moment, Harvoni is the only compound available as STR approved in Poland for interferon-free treatment of HCV infection. It shows few interactions with other drugs, which is especially important in patients with HIV co-infection, who take antiretroviral drugs. Harvoni is highly effective and very well tolerated even by people with liver cirrhosis or HIV/HCV co-infection.

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