Idiopatyczny przewlekły kaszel – przesłanki dotyczące leczenia gabapentyną

© Borgis - Medycyna Rodzinna 2/2014, s. 59-63

Anna Staniszewska^{1, 2}, Bożena Tarchalska-Kryńska¹

Summary
Chronic idiopathic cough is defined by cough in the absence of an identifiable cause. Cough is an important clinical problem, which is often connected with difficulties during differential diagnosis and treatment. The chronic cough has negative effects on HRQOL of patients in many aspects including physical, psychological and social domain. The management of patients with chronic cough is challenging on many fronts. Antitussives usually don’t work, so searching for a new drugs. The article reviews literature of the effect of gabapentin on chronic idiopathic cough. The reports reveal that the treatment of chronic idiopathic cough with gabapentin is both effective and well tolerated. Similarities between central reflex sensitisation in refractory chronic cough and neuropathic pain suggest that neuromodulators such as gabapentin might be effective for refractory chronic cough. Further randomized, placebo controlled studies are warranted to confirm these findings and more research is needed to unravel the mechanisms by which gabapentin improves cough.

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