Przeciwgrzybicze działanie olejku goździkowego

*Anna Kędzia¹, Marta Ziółkowska-Klinkosz¹, Łukasz Lassmann², Barbara Kochańska², Aida Kusiak³, Alina Gębska¹, Anna Wojtaszek-Słomińska⁴

Summary
Cloves (Eugenia caryophylata Thunb, syn. Syzygium aromaticum (L.)Merr. Et Perry) are the aromatic dried flower buds of a tree in the family Myrtaceae. Clove oil can be obtained from the flower buds. The essential oil is widely used and well known for its medicinal properties. Several constituents of clove oil has been identified, mainly eugenol and lesser amounts of other compounds such as acetyleugenol, isoeugenol, α- and β-caryophyllene, α- and β-pinene, limonene, benzyl acid and alcohol and cinnamaldehyde. Several studies have demonstrated potent antibacterial, antifungal, antiviral and insecticidal effect of essential oil of clove. A total 36 strains of yeastlike fungi isolated from patients with oral candidosis and 6 standards strains were tested. The susceptibility (MIC) yeastlike fungi to clove oil was determined by means plate dilution technique in Saboraud’s agar. The inoculum contained 10⁵ CFU per spot were seeded with Stars replicator upon the surface of agar containing oil and without clove oil agar plates (the strains growth control). The cultures were incubated in aerobic conditions at 37°C for 24 hrs. The MIC was defined as the lowest concentrations of oil that completely inhibited growth of tested strains. The results indicated, that the most susceptible to clove oil were strains from the genus of Candida utilis (MIC = 0.25 mg/ml). The clove oil exhibited strong antifungal activity against the strains from the genus of C. albicans, C. glabrata, C. guilliermondii and C. tropicalis too. The growth of these strains were inhibited within the range from 0.25 to 0.5 mg/ml. Furthermore high level of activity was observed against the strains from the genus of C. krusei, C. lusitaniae and C. parapsilosis (MIC = 0.5 mg/ml). The strains C. kefyr were the lowest sensitive. The growth of these strains were inhibited within the range from 0.5 to 1.0 mg/ml.

To jest tylko fragment artykułu. Aby przeczytać całość, przejdź do Czytelni medycznej.