Antiamnesic activity of Solanum melongena L. extract

Soma Manasa, *Akondi Butchi Raju

Summary
Solanum melongena L. (egg plant) is proved to contain antioxidant and neuroprotective agents. So we evaluated the antiamnesic activity of the present extract.
Antiamnesic activity was evaluated using scopolamine, an inducing agent and memory disruptor and employed various behavioral and biochemical parameters like radial arm maze test, active avoidance test. Acetylcholinestarase activity in the brain was measured and oxidative stress was also determined.
Dose dependent reduction in the working and reference memory errors were identified in radial arm maze test. Increased active avoidances were reported after treatment with high dose of extract (400 mg/kg) in active avoidance testing. Acetylcholinestarse levels and oxidative stress parameters were maintained normal in extract treated groups and the values are comparable to standard drug piracetam treatment.
Based on the results of behavioral and biochemical studies, hypothesize that egg plant extract may act directly as a free radical scavenger or regulator to inhibit acetylcholinesterase due to the presence of phytoconstituents mainly flavonoids, polyphenols which might be responsible for exhibiting antiamnesic activity.

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