An educational model of glucose homeostasis in diabetes mellitus

*Mihály Dió¹, Tibor Deutsch¹, Judit Mèszáros²

Summary
A simulation model of glucose homeostasis in diabetes mellitus could be very useful for patient, student and health-carer training. In this paper, the first design phase of the modelling work is presented. The new comprehensive educational model of glucose homeostasis described in this report attempts to provide an anatomically explicit basis for simulations that incorporates up-to-date quantitative knowledge about glucose metabolism and its control by insulin. The overall glucose homeostasis model consists of differential mass balance equations complemented by differential or algebraic relationships for each metabolic source or sink term. Major clinical parameters such as basal glucose and insulin levels along with hepatic glucose production are used for customizing the model for individual patients. The educational model allows the simulation of 24-hour blood glucose (BG) profiles for non-diabetic subjects as well as for people with insulin-dependent (type 1) diabetes mellitus (IDDM) and non-insulin dependent (type 2) diabetes mellitus (NIDDM). Graphs of the model functions are provided, and example simulations are shown demonstrating the inner workings of the model.

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