Rola cząsteczki CXCL8 w patogenezie zapalenia przyzębia

*Andrzej Miskiewicz¹, Grzegorz Szparecki²

Summary
Periodontitis is a heterogeneous group of diseases which derive from the impact of dental plaque on the immunological system of the host. Periopathogens present in the bacterial plaque stimulate various mechanism mostly of an innate immunity therefore the inflammation in periodontal tissues occurs. The main signs of periodontitis are the following: loss of periodontal attachment, increased probing depth, proteolysis of bone tissues surrounding the tooth, and finally bleeding on probing which accounts for an active inflammatory process. The visible signs of periodontitis, detected on clinical examination are the results of triggering specific pathways of inflammatory gene expression. The main group of cytokines responsible for the ongoing inflammatory process consists of interleukins. A is a crucial chemokine produced by monocytes in periodontal tissues. Due to its various forms released in the ongoing site of infection, the chemokine may have a different effect on the neutrophils and fibroblast which take part in the immune response of periodontitis. Up-to-date there has been a little research performed over the activity in periodontitis therefore it is important to clarify and confirm its contribution to the inflammatory process.

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