Analiza epidemiologiczna występowania Candida species oraz ich lekooporności u pacjentów ze stomatopatią protetyczną**

*Andrzej Miskiewicz¹, Grzegorz Szparecki², Maciej Nowak¹, Renata Górska¹

Summary
Introduction: Currently a disquieting increase of oral candidosis in patients using removable dentures with acrylic plate has been noticed. When untreated, the condition leads to prosthetic stomatopathy which is characterized by dry and burning mouth symptoms. On clinical examination changes on mucous membrane in oral cavity are visible. They are placed under prosthesis plate and present as little plaques, erythema or granulomatosis.
Aim: The objective of the study was to confirm and establish the prevalence of oral candidosis in patients diagnosed with prosthetic stomatopathy. Furthermore it was crucial to ascertain drug-resistance of Candida against classically used antifungal agents.
Material and methods: A real-time PCR was performed in order to detect Candida spp. DNA in the group of 15 patients diagnosed with oral stomatopathy according to Newton’s classification and confirmed by cytological detection of oral Candida. The biological material was taken from oral mucosa and acrylic plate of dentures.
Results: In all of the patients, diagnosed with a prosthetic stomatopathy, a significant amount of total Candida load and Candida albicans colonization were discovered. The C. albicans isolated from the patients was fully resistant to fluconazole. The resistance levels against ketoconazole and natamycine were also high (> 75%).
Conclusions: In the light of growing resistance against commonly used antifungial drugs it seems necessary to develop new method of prophylaxis and therapy, which would not induce multidrug resistance and cause dangerous adverse effects.

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