Terapia fagowa – nadzieje i obawy

*Paweł Kowalczyk¹, Karol Chalimoniuk², Agnieszka Danielak², Dorota Dziedziela², Paulina Jankowska², Marzena Kowalska², Joanna Laskowska², Marzena Rachocka², Jarosław Szczepaniak², Tomasz Walter², Paulina Strzyga², Justyna Szymańska², Mariusz Słomka², Katarzyna Zawadka², Martyna Staszewska²

Summary
After the first treatment of bacterial infections bacteriophages specific to them was applied by a doctor Felisa d’Herelle in 1919 for the treatment of bacterial dysentery. In the 20 years between the wars and after the war, was very popular in the countries of the former Soviet Union, in addition to standard treatment with antibiotics. At present, the European Union is experiencing slow phage therapy „renaissance” and begins to be regarded as one of the safer ways to treat bacterial diseases that are resistant to a certain antibiotic. Within the European Union there are currently the only facility specializing in research on therapeutic applications of bacteriophages since 1952, which is the center of phage therapy NZOZ working at the Institute of Immunology and Experimental Therapy them. Louis Hirszfeld in. The Institute has modern methods for the isolation of bacteriophages for the preparation of phage preparations used in experimental treatments (antibiotic-resistant bacterial infections by bacteriophages) in accordance with the Declaration of Helsinki. The indications for the use of phage therapy may be a bacterial infection of the whole organism, both exterior coatings such as skin and internal organs such as the bones and joints. Phage therapy is used only when all conventional methods of treatment of infections (infections) battery failed. One of the qualifying factors necessary to carry out the execution of phage therapy at the Centre – phage typing. If the result is positive, this means that you can prepare phage preparation. They may be used either orally or rectally. Phage preparations prepared with support from phage collection of the Institute of Laboratory bacteriophage which are sensitive to phages selected bacteria of cocci (coccus), such as Staphylococcus, Enterococcus, and gram-negative bacteria belonging to the family Enterobacteriaceae, e.g. Enterobacter, Escherichia, Citrobacter, sticks gastrointestinal tract: Klebsiella, Shigella, Serratia, Salmonella, proteobakterii family that can cause opportunistic infections: Proteus, Pseudomonas, Stenotrophomonas, Acinetobacter and Bulkholderia.

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