Eleuterozydy. Ich budowa, właściwości biologiczne i działanie lecznicze

© Borgis - Postępy Fitoterapii 2/2013, s. 118-122

*Daniel Załuski, Zbigniew Janeczko

Summary
Eleutherosides are the main, chemical compounds present in species from the Eleutherococcus Maxim. genus, which are native to eastern Asia and north Russia. The first attempts at their isolation and identification were taken in the 60’s of the twentieth century. As a result of this, seven compounds were isolated, called as eleutherosides A, B, C, D, E, F, G. In the 70’s additional compounds were obtained, such as eleutherosides I, K, L, M, B2, B3, B4. However, their final, chemical structure was elucidated in the late 70’s and early 80’s. Taking into account an aglycone type, eleutherosides were divided into four groups of secondary metabolites, such as glycosides of coumarin, lignans, sterols and triterpenic acids. Main attention in pharmacokinetic and pharmacological studies was given to eleutheroside B and E, the compounds that occur in the predominantly. According to FP IX, their total content can not be less than 0.08% (80 mg/100 g of raw material). Eleutherosides have a wide biological activity. They are the only ones among the few compounds that have adaptogenic property, moreover they improve nonspecific body resistance and resistance to stressors internal and external origin. As well as, they improve the learning and mental processes.

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