Wrażliwość chemoreceptorów ośrodkowych u młodych, zdrowych osób palących papierosy i niepalących papierosów**

Kamila Ludwikowska¹, Bartosz Katkowski¹, Małgorzata Lubieniecka², Agnieszka Rydlewska^{3, 4}, *Ewa A. Jankowska^{3, 4}

Summary
Introduction. Central chemoreceptors modulated by autonomic nervous system play a crucial role in regulation of the ventilatory response to changes of carbon dioxide concentration in circulating blood. Central chemosensitivity (chemo) has been studied mainly in patients with heart failure (HF) in whom it is augmented, and in healthy age-matched (> 50 years old) controls. The aim of this study was to assess chemo in young healthy students and to measure the differences in chemo bewteen men vs. women and smokers vs. non-smokers.
Material and methods. 25 young healthy men (age: 24 ± 2 yr, BMI: 24.0 ± 2.6 kg/m²) and 20 young healthy women (age: 24 ± 2 yr, BMI: 20.4 ± 2.0 kg/m²) including 11 men and 5 women smoking cigarettes were examined. Chemo was assessed with “rebreathing” method (breathing within a closed circuit: the subjects exhaling CO₂ which resulted in a steady increase of CO₂ concentration within a circuit and subsequently in circulating blood of an examine person; thus, subjects developed hypercapnia, which in turn in a chemoreflex manner induced hyperventilation). Chemo was defined as the slope of the regression line relating VE to PETCO₂ concentration (expressed in L/min/mmHg)
Results. Chemo values averaged from 0.05 to 2.53, mean: 0.69 ± 0.54 L/min/mmHg. There were no differences in chemo between men and women as well as between smokers and non-smokers.
Conclusions. The values of chemo in healthy young were presented in this study. Neither sex nor smoking cigarettes diversified chemo values.

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