Aktywność antyoksydacyjna preparatów z morwy białej, fasoli zwykłej oraz miłorzębu japońskiego w cukrzycy generowanej podaniem streptozotocyny

*Agnieszka Greń

Summary
In the course of diabetes, an increase in oxidative stress occurs as a result of uncontrolled formation of free radicals (ROS). Basic protection is provided by the so-called enzymatic triad: superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). The main component of the non-enzymatic antioxidative barrier is glutathione (GSH). One of the treatment strategies is using plant compounds or preparations as protective agents that support the therapy of diabetes. The aim of this work was to investigate the antihyperglycemic, antioxidant and antihyperlipidemic effects of the aqueous extract of white mulberry, Ginkgo biloba and Phaseolus vulgaris on streptozotocin (STZ) – induced diabetic mice.
Diabetes was induced in Swiss albino mice by the administration of STZ (65 mg/kg b.w.) intraperitoneally. Aqueous extract of white mulberry, Phaseolus vulgaris and Ginkgo biloba were administered by oral gavage once a day for a period of 15 days. The effect of the extracts on enzymatic and non-enzymatic antioxidants of defence systems such as SOD, CAT, GPx and GSH levels in blood serum was studied.
Our results showed that white mulberry, Phaseolus vulgaris and Ginkgo biloba extracts reduced the blood glucose. As a result of studies carried out it was found that diabetes increases the oxidative stress causing perturbation of the redox homeostasis of the body. The applied plant preparations do not lead to full metabolic control, however, they may have potential protective activity through the stimulation of the antioxidative system in the body.

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