Wpływ wybranych roślin leczniczych na aktywność glikoproteiny P

*Adam Klimowicz¹, Małgorzata Jeziorna¹, Anna Nowak¹, Stanisława Bielecka-Grzela²

Summary
Adenosine-triphosphate (ATP)-binding cassette (ABC) superfamily is a great group of transporters localised inside cell membrane. They translocate a great variety of cationic, hydrophobic and amphoteric compounds, including drugs, out of the cells, at the expense of ATP hydrolysis. Up to now about 50 proteins belonging to this family, has been identified, from which P-glycoprotein (P-gp) seems to be one of the most important transporters. By regulation of transmembrane efflux it plays a crucial role in cell protecting from accumulation of exogenic as well as endogenic toxic compounds. A lot of drugs, differing in chemical structure and pharmacological properties as well, are the subjects for P-gp. Except drugs, a couple of other substances, including food components, herbal products, diet supplements or ingredients of frequently applied spices, can influence of P-gp activity drug concentration. These compounds can decrease or increase drug concentration and then can influence on therapeutic effect as well as can induce side-effects in certain cases. For instance, the influence of grapefruit as well as orange juice on the pharmacokinetics of some therapeutics is well-known example. In the paper the impact on P-gp activity of certain plants ingested as food components or as OTC herbal products is presented. Due to the content of compounds active against P-gp, the following herbals: St John’s wort, Curcuma longa, black pepper and long pepper, milk thistle, hot red pepper, Ginkgo biloba and/or green tea should be taken into consideration. In certain cases they can interact unfavourable with some drugs administered at the same time.

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