D-dimer w zakrzepicy żył głębokich kończyn dolnych

*Marzenna Galar, Anna Szumowska, Elżbieta Tajanko, Łukasz Bołkun, Janusz Kłoczko

Summary
Introduction: Deep vein thrombosis (DVT) is a significant problem in clinical practice. D-dimer, the final degradation product of cross-linked fibrin, is an established parameter for ruling-out the disease and serves as a supplementary test in diagnostic imaging.
Aim: The aim of the following study was to estimate plasma concentration of D-dimer in reference to the size of thrombosis as well as D-dimer reliability in the diagnose and monitoring of DVT treatment.
Material and methods: Twenty-seven patients with newly diagnosed DVT confirmed by phlebography was evaluated. The influence of anticoagulant treatment on D-Dimer concentration was assessed in 10 patients during twelve-weeks therapy of low-molecular-weight heparin. The plasma concentration of D-dimer was measured by enzyme immunoassay, using ENZYGNOST D-dimer micro kit, Dade Behring.
Results: The results demonstrated, that the patients with DVT had a significant increase in plasma concentration of D-Dimer. No correlation was found between D-Dimer concentration and the size of thrombosis in the phlebography examination. During low-molecular-weight heparin treatment, a progressive decrease in D-dimer plasma concentration was observed, reaching – at the end of treatment – a concentration value, approximate to the healthy control. Furthermore, a 100% specificity for D-dimer testing with a 81.1% negative predictive value was achived.
Conclusions: We conclude that growth of D-Dimer concentration in plasma is a sensitive and reliable indicator of DVT. The measurement of the D-Dimer plasma concentration is a reliable test in the diagnose and monitoring of the efficacy of DVT treatment.

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