Zarostowe zapalenie oskrzelików z organizującym się zapaleniem płuc

*Violetta Matkowska¹, Ewa Jankowska¹, Marek Marciniak², Konrad Pawełczyk², Sylwia Robak³

Summary
Bronchiolitis obliterans organizing pneumonia (BOOP) was first described in 1985 by Epler. BOOP is an idiopathic inflammatory disease, sometimes caused by viruses, bacteria, fungus, drugs or chest radiotherapy.
The main symptoms are dry cough, fever, weight loss and effort dyspnoea – rarely hemoptysis. In its course the disease usually resembles a flu infection of medium intensification which lasts a few weeks.
In diagnostics the most useful examinations are lung x-rays and chest high-resolution computer tomography. However, confirmed diagnosis can be done on the basis of histopathological tests of lung biopsy specimen – in the lumen of terminal bronchioles and alveoli the mass of the connective tissue composed of fibroblasts and mononuclear cells, in the maintenance of pulmonary parenchyma, is detected.
In the usual treatment corticosteroids are applied for one year, the treatment can be shortened to six months in the case of some patients. In steroid-resistant cases cytostatics are applied. Most often, there is a fast clinical amelioration, however, among some patients rapid progress of the disease, leading even to death, can be observed.
Patients with solitary pneumonic involvement who have had the lesion surgically removed do not need additional prednisone treatment. Complete remission is achieved in 60-80% of the patients.
The disease recurrence takes place relatively frequently, especially when the treatment is too short or the drug doses are reduced too early. Then, it is treated with steroids.

To jest tylko fragment artykułu. Aby przeczytać całość, przejdź do Czytelni medycznej.