Przeciwbakteryjne działanie Solarenu

*Anna Kędzia

Summary
The sensitivity to Solaren of 31 strains of anaerobic bacteria and 34 aerobic bacteria isolated from infections of oral cavity, respiratory tract and intestinal tract were tested. The susceptibility was performed by means of plate dilution technique in Brucella agar (anaerobes) and Mueller-Hinton agar (aerobes). The inoculum containing 10⁵ CFU per spot was seeded Steers replicator upon the surface of appropriate agar with and without the herbal drug (strains growth control). Incubation was performed at 37°C for 48 hrs in anaerobic jars under anaerobic conditions (anaerobes) and at 37°C for 24 hrs in aerobic conditions (aerobes). The MIC was defined as the lowest Solaren concentrations that completely inhibited the growth of tested bacteria. The results indicated that from anaerobic Gram-negative bacteria only 4 strains were susceptible in concentrations in ranges from 25.0 to 15.0 mg/ml. The growth of remained strains were inhibited by concentrations ≥ 30.0 mg/ml. The Gram-positive anaerobes were the more susceptible. The concentrations in range from 20.0 to 3.7 mg/ml inhibited the growth of 67% of these bacteria. Against Gram-negative aerobic bacteria activity to Solaren was poor (MIC ≥ 30.0 mg/ml). But aerobic Gram-positive cocci and rods were susceptible to herbal drug in concentrations from 20.0 to 7.5 mg/ml (64%). Solaren was most effective against Gram-positive than Gram-negative anaerobes and aerobes.

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