Rola komórek dendrytycznych w immunoterapii chorób rozrostowych układu krwiotwórczego

Jacek Roliński

Summary
Dendritic cells are the professional antigen-presenting cells. They play a crucial role in the activation of naive T cells in vivo, therefore they are probably the best adjuvant for cancer immunotherapy. Studies on dendritic cells have been greatly limited by difficulties in preparing the sufficient numbers of cells. Greater understanding of dendritic cells biology and function has led to successful strategies for generating dendritic cells from in vitro culture systems. GM-CSF and TNFα are the two main cytokines necessary for dendritic cells generation from peripheral blood or bone marrow CD34+ stem cells. Dendritic cells can also be generated from peripheral blood CD14+ monocytes in the presence of GM-CSF and IL-4. In this paper, I briefly review the main features of dendritic cells that are important for immunotherapy of leukaemia and lymphoma and discuss the various strategies to vaccinate patients with dendritic cells.

To jest tylko fragment artykułu. Aby przeczytać całość, przejdź do Czytelni medycznej.