Ziele dziurawca zwyczajnego – składniki czynne i potencjalne zastosowania lecznicze

Sebastian Turek

Summary
St. John´s wort is Hypericum perforatum L., Hypericaceae, a herbaceous perennial plant native to western United States, Europe and Asia, and its various preparations are widely used for the treatment of some disorders. The article presents the appearance of the plant and the stock, the chemical composition with regard to biological active compounds and indication. The flavonoids (rutin, quercetin, and isoquercetin), hypericin and hyperforin are the main active substances of St. John´s wort. They support regeneration of human body cells, provide disinfection, and act as antiviral and anti-inflammation tools. Hyperforin has also been shown to have antimicrobial activity against Gram-positive bacteria. The antitumor properties of St. John´s wort are attributed to hypericin, which is a powerful photosensitizer. Once taken up by tumor cells, hypericin reacts in the presence of oxygen and activates multiple apoptosis pathways that results in malignant cell death. But the most common indication of St. John"s wort is the treatment of mild-to-moderately severe depressive disorders.

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