Aktywność biologiczna flawonoidów

Justyna Ostrowska, Elżbieta Skrzydlewska

Summary
Flavonoids are benzo-g-pirone compounds occuring in plants – in fruit and vagetables in particular – as well as in tea. Due to polyphenol structure of its particle, these compounds may protect cells against the toxic action of reactive oxygen species (ROS). Their antioxidative properties are connected with their ability to scavenge free radicals and the other oxidants, to chelate cupper and iron ions, to inhibit prooxidative enzymes activity, to induce enzymatic antioxidants and to protect non-enzymatic ones (preventing oxidation of small molecular antioxidant – a-tocophetol, ascorbic acid). Therefore flavonoids reveal properties to protect biological membranes against ROS action through prevention enzymatic and non-enzymatic lipid peroxidation and direct interaction with biological membrane. In addition to their proved antioxidative actions, flavonoids can influence the intensification of ROS generation in the presence of transitions metal ions, revealing prooxidative action in this way. Flavonoids also modify metabolism of xenobiotics, including carcinogens, through results of studies dealing with this problem are unonimous. Due to modification of cellular redox status as well as xenobiotics metabolism and inhibition of kinase activity, flavonoids slow down cancerogenic process.

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