Wpływ leczenia 5ASA na wykładniki stresu oksydacyjnego u dzieci z nieswoistymi zapaleniami jelita grubego

Iwona Ignyś¹, Hanna Krauss², Waldemar Malewski¹, Przemysław Sosnowski², Marian Krawczyński¹

Streszczenie
The aim of the study was evaluate: the exponents of antioxidantive and prooxidantive mechanisms in the course of inflammatory bowel disease, if the application of treatment leading to clinical remission is connected with the changes of the examined mechanisms.
The study was performed in a group of 35 children aged 8-17 with IBD, which divided into three subgroups: I. (14 children) with UC, II. (6 children) CD, III. (15 children) NC. The obtained results were compared with 15 children´s control group (IV).
The diagnosis was made on the basis of care history, clinical evaluation of morphological picture in colonoscopy and/or rectoscopy connected with histological evaluation of colon mucosa.
The level of malonyldialdehyde (MDA) in blood was marked acc. to Okhawa´s method, and the activity of sodium dismuthase (SOD) (by means of Misra-Fridovich´ method) before, 3 and 6 month after treatment.
The increase of prooxidantive processes was stated, particularly in the group of IBD children. The applied treatment decreased but not normalized the exponents of prooxidantive processes in children with IBD. It was proven that domination of prooxidantive processes and significant decrease of enzymatic proteins´ activity may constitute a potential mechanism of tissue damage in gastrointestinal inflammatory conditions and at the same time suggests the possibility of applying new antioxidantive therapy.

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