Podstawy immunogenetyki w chorobach autoimmunologicznych u dzieci

Henryk W. Witas, Jerzy Bodalski

Streszczenie
The term autoimmunity encompasses a variety of polygenic diseases ranging from organ specific disorders such as diabetes mellitus, multiple sclerosis or celiac disease to systemic ones such as lupus erythematosus. Genetic predisposition as well as many environmental factors may contribute to pathogenesis of autoimmune disorders. It seems that the most intriguing feature recently studied, which probably is the main pathology target is lymphocyte activation i.e. primary and secondary signal both generated to get started proliferation of specific T cell clones. A number of molecules involved in T cell activation is known, and others are still being discovered as the search for candidate genes, which form predisposing genotype is continued. This object of direct or indirect studies could show itself as a means of possible therapeutic intervention through the direct modification of genes or protein products of their expression.

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