Uzasadnienie leczenia klenbuterolem niektórych chorób ośrodkowego układu nerwowego

Andrzej Brzecki

Streszczenie
In the pictures the results of sympathetic cerebropetal exclusion in an experimental osmotic and angiogenic edema influenced by stimulants and anaesthetic´s factors are presented. The results are in accordance with the latest research and they confirm the reports concerning significance of astrocyte in a role of an intermediary in the blood ... barrier and sensibility of brain tissues that is connected their neurobiological activity. Low responsiveness to stimuli of brain tissues and changes in brain microvessel permeability (e.g. in a coma) results in inhibitory stimulation (GABA-ergic).
The above, as well as other mentioned data, prove that adrenomimetic medicines work neuroprotectively and that they affect brain activities connected with both a local blood flow and neurochemical stimulation. The issue of neuroprotective factors has been explicated and the significance of adrenomimetics-clenbuterol which stimulates beta₂-adrenoreceptors of transverse striated muscles and protects brain by means of brain derived neurothropic factors (BDNF) has been emphacised. On this basis, we have put forward the hypothesis about neuro-degenerative CNS illnesses´ treatment. The significance of adrenergic neurotransmitters and other stimulation of a central regulation and some possibilities of administration of beta₂-adrenomimetics in some motor disturbances of CNS has been discussed. The usefulness of application of clenbuterol in children cerebral palsy has been motivated. Clenbuterol has been used in the treatment in Rehabilitation Centre in Mikoszów near Strzelin. It has turned out that this well known medicine in asthma treatment, of both children and adults, showing practically no side effects, is useful in treatment of children with some disturbances of the central narvous system, in particular, with various sorts of motor hyperexcitability, and moreover, with motor paresis.

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