Fizjologiczne podstawy działania leków przeciwpadaczkowych

Bartosz Godlewski¹, Karol Jastrzębski², Krzysztof Zapałowicz¹

Streszczenie
The main method of treatment of epilepsy is pharmacology. Pharmacology should be preceded be precise diagnostic. Mechanisms of action of antiepileptic drugs has been discovered relatively not long ago. Prior ignorance of these mechanisms of action didn´t limit their usefulness, but understanding the mechanisms helps in clinical practice. Thanks to this knowledge antiepileptic drugs can be used more rationally and effectively, especially in multidrug regimens. To understand and remember mechanisms of action it is necessary to have knowledge of physiology of nervous system. Many structures and processes are involved in the development of a seizure, including ion channels, neurotransmitters, receptors and synapses. The article includes information about physiology as well as pharmacology. The role of GABA (gamma-aminobutyric acid) receptors, sodium and potassium channels in generating of action potentials and in ethiopathology of seizures are described.

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