Osteoporoza w zapalnych chorobach stawów

© Borgis - Nowa Medycyna 3/2004

Agnieszka Sulik, Karol Kita, Bogdan Lewandowski, Izabela Domysławska, Otylia Kowal-Bielecka, Piotr Adrian Klimiuk, Stanisław Sierakowski, Zenon Chwieśko

Streszczenie
Rheumatic diseases are often associated with changes in bone metabolism. Excessive production and release of cytokines and other growth factors due to inflammation, e.g. tumor necrosis factor-alpha (TNF-alpha), interleukins such as Il-1 and Il-6, may cause alterations in bone homeostasis leading to bone degradation. Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular osteopenia is a hallmark of rheumatoid arthritis, the prototype of inflammatory arthritis. In this article we review the patogenesis of inflammatory bone loss and explore the possible therapeutic interventions to prevent it.

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