Znaczenie diagnostyki zakażeń wirusem HPV w profilaktyce raka szyjki macicy

*Joanna Świderska

Streszczenie
Human Papilloma Virus, HPV, belongs to the Papoviridae family and is known to be the most common cause of genital infections. Till present, are identified more than 100 genotypes of this virus, which have also been shown to be host-specific. According to the actual data, HPV infection is the most important risk factor leading to the development of Cervical Intraepithelial Neoplasia (CIN) and cervical cancer. The latest studies, that used PCR as detection method, showed that HPV DNA is present in more than 90% invasive cervical carcinomas, and found out that there are several types of Papillomavirus directly implicated in the initiation of carcinogenesis.
World-wide epidemiological studies have shown that cervical cancer is, after breast cancer, the second most common malignant tumor in women. In Poland over 6500 new cases of this disease are diagnosed every year. .
The most effective method for the diagnosis of a HPV infection is the detection of viral DNA by PCR (Polymerase Chain Reaction) and its variant, real-time PCR. This novel and developing technique allows a precise quantification of the genetic material present in a tested sample with highest accuracy than other diagnostic tests available.
In this article, we summarized the conclusions of the studies concerning HPV and cervical cancer, published till now.

To jest tylko fragment artykułu. Aby przeczytać całość, przejdź do Czytelni medycznej.