The influence of perindopril on lipid peroxidation and the oxidase activity of ceruloplasmin in the blood of old age patients with primary hypertension

Tomasz Kornatowski¹, Kornelia Kedziora-Kornatowska², Hanna Pawluk³, Jozef Kedziora³, Leszek Szadujkis-Szadurski¹, Robert Pawluk³, Jolanta Czuczejko³, Jadwiga Motyl²

Summary
Background: The purpose of this work was to estimate oxidase activity of ceruloplasmin and lipid peroxidation processes in the blood of elderly patients with primary hypertension. Furthermore, the influence of treatment with ACEi, perindopril, on the examined parameters was determined.
Material and methods: The research was carried out on 28 patients (65-91 yrs) with primary hypertension, treated with perindopril for 6 weeks, and normotensive persons who constituted the control groups: 25 (65-96 yrs – K₁) and 23 (22-41 yrs – K₂). The oxidase activity of ceruloplasmin was measured in serum by Ravin´s method, and the concentration of malondialdehyde (MDA) in erythrocytes according to Placer et al. Patients with hypertension underwent an examination after 7 days and 6 weeks from the beginning of therapy.
Results: It was found that in the group of patients with hypertension, the activity of ceruloplasmin was significantly higher in comparison to the activity in the control groups (K₁ and K₂). The concentration of MDA in erythrocytes of patients with hypertension was significantly higher than in the control groups (K₁ and K₂). In patients with hypertension, after 7 days of therapy a substantial decrease in the oxidative activity of ceruloplasmin was found, but the lowest value was observed after 6 weeks of therapy. These values were significantly lower than those from the control groups.
Conclusions: The results confirm the intensification of oxidative stress in elderly patients with primary hypertension and point to the beneficial antioxidant effect of perindopril.

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