The impact of Q10 on selected structural and functional parameters of red blood cells in old-age patients with primary hypertension

K. Kujawski¹, M. Koter¹, P. Duchnowicz¹, Kornelia Kedziora-Kornatowska², Tomasz Kornatowski³, Leszek Szadujkis-Szadurski³, Jozef Kedziora⁴, Leszek Markuszewski¹, R. Blaszczak¹

Summary
The free radical theory of ageing assumes that in the older organism its oxidative balance gets shattered. Both arterial hypertension and oxidative stress cause structural and functional changes in the erythrocytes. Q10 is a compound which plays important roles in the cell and in its antioxidative properties, and may to a certain extent prevent unfavourable changes in the erythrocyte. Its amount in the human organism gradually decreases with age. The aim of this research was to evaluate membrane lipid peroxidation, inner microviscosity, and membrane ATPase activity in old-age normotensive and primary hypertensive patients before and after applying Q10.
The study was performed on 42 patients divided into three groups. The first two composed old-age patients with and without an accompanying hypertension. The third, control group consisted of healthy patients aged 51-59. In all three groups are shown the original parameters of red blood cells. In the case of elderly people the parameters were additionally recorded after three and six weeks of the Q10 application.
Membrane lipid peroxidation was found to be strongest in the both groups of elderly people, and the weakest in the control group. The application of Q10 resulted in a decrease in this parameter in both groups. The activity of total and Na⁺K⁺ dependent ATPase appeared the greatest in the control group, and the lowest in the group with hypertension. Q10 supplementing in the two groups caused the intensification of total and Na⁺K⁺ dependent ATPase activity. The highest value of inner microviscosity was observed in people with hypertension, and the lowest in the control group. After the application of Q10 it declined in both groups.
The results may point to a very beneficial effect of supplementary and metabolic therapy on structural and functional parameters in elderly people, especially with an accompanying arterial hypertension.

To jest tylko fragment artykułu. Aby przeczytać całość, przejdź do Czytelni medycznej.