Zastosowanie peptydu natriuretycznego typu B w kardiologii dziecięcej oraz u dzieci bez patologii układu sercowo-naczyniowego

Jacek Skiendzielewski, *Bożena Werner

Summary
B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are released mainly by cardiomyocytes as a result of wall stress of heart chambers. BNP and NT-proBNP levels are physiologically highest in the first days of life. They gradually decrease reaching the levels similar to adults in preschool-age children.
BNP and NT-proBNP levels correlate with hemodynamic disturbances and clinical signs of heart failure in children with congenital heart anomalies. The assessment of BNP and/or NT-proBNP is useful in patients with dilated cardiomyopathy and pulmonary hypertension in monitoring the effectiveness of pharmacologic treatment.
In some cases it has been observed that BNP and NT-proBNP help to differentiate cardiogenic symptoms and signs from noncardiogenic ones. They can indicate cardiologic complications in certain chronic diseases. It should be always taken into consideration that e.g. brain oedema or severe infection may influence BNP and NT-proBNP results without cardiac involvement.

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