Abdominal hernia repair surgery with the new injectable polymer biomaterials

*Labib Zair¹, Jędrzej Skrobot², Mariola Marchlewicz³, Jarosław Lichota¹, Leonard Gugała⁴, Magdalena Kuczyńska⁵, Samir Zeair⁶, Ewa Duchnik⁷, Karol Tejchman¹, Barbara Wiszniewska⁸, Jerzy Sieńko¹, Tadeusz Sulikowski¹, Marek Ostrowski¹, Mirosława El Fray²

Summary
Introduction. The new injectable polymer biomaterials offer a completely innovative approach to hernia repair surgery. This study evaluated the potential application of injectable polymer biomaterials in hernia treatment using an animal model. Local connective tissue reactions associated with the new injectable polymer biomaterials were compared with the reactions provoked by commercial polypropylene mesh.
Aim. Evaluation of the potential application of injectable polymer biomaterials in the treatment of abdominal wall hernias using an animal model.
Material and methods. Five groups of rabbits with previously-created hernias were treated with new biomaterials injected in nonpolymerized form into hernial openings. The same animals had previously polymerized discs surgically implanted in the dorsal subcutaneous area. The rabbits were kept under clinical observation for 28 days, then sacrificed under anesthesia. Samples of subcutaneous tissue were taken from the hernia region and from the vicinity of the polymerized biomaterial discs implanted in the dorsal area for histological examination.
Results. In groups 1, 2 and 3, hernia treatment results, laboratory tests and histological examination of the tissues previously taken from the operated hernia sites were similar to the results obtained in the control group. In groups 1, 2 and 3, the numbers of fibrocytes and neutrophils in the vicinity of the subcutaneously-implanted discs in the dorsal area were similar to those in the hernial region treated with mesh in the control group.
Conclusions. Biomaterials 188-UR/PEG-DA 85/15, P1838-DMA and 1838_UR can be used in animals in the near future as possible abdominal wall hernia treatments. These biomaterials were as efficient as the polypropylene mesh used in the control group for treating abdominal wall hernias.

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