Działanie preparatu Salviasept na bakterie beztlenowe wyizolowane z zakażeń jamy ustnej i górnych dróg oddechowych

Anna Kędzia¹, Andrzej W. Kędzia²

Summary
The sensitivity to Salviasept (Herbapol, Lublin) of 107 strains of anaerobic bacteria isolated from patients with infections of oral cavity (25) or upper respiratory tract (14) and 4 standards strains were tested. The susceptibility (MIC) anaerobes was determined by means of plate dilution technique in Brucella agar supplemented with 5% defibrinated sheep blood, menadione and hemin. Inoculum containing 10⁶ CFU per droplet was seeded with Steers inoculator upon the surface of agar containing various Salviasept concentrations as well as upon that with no drug added (strains growth control). Incubation was performed in anaerobic jars in anaerobic conditions, at 37°C for 48 hrs. MIC was regarded as the minimal Salviasept concentration that completely inhibited growth of the strains anaerobic bacteria. The results of these investigations indicated that the most susceptible to Salviasept were the strains to the genera Bacteroides (50%), Prevotella (48%), Propionibacterium (50%) and Gram-positive cocci (53%). The MICs of these strains were within the ranges from Ł 0,6-2,5 mg/ml. The strains of Actinomyces spp. and Eubacterium spp. were less sensitive. The growth of 67-80% of these strains were inhibited by Salviasept within the range from 5,0 to ł 20,0 mg/ml. The strains of Veillonella spp. were the lowest sensitive (MIC in ranges 15,0 to ł 20,0 mg/ml).

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