Terapia fotodynamiczna – jej oddziaływanie i zastosowanie w dermatologii

*Janusz Fornalski

Streszczenie
The goal of PDT is the selective destruction of targeted abnormal cells while preserving normal structure. Photodynamic therapy offers the potential of an effective new treatment in several areas of medicine. The initial step to PDT is the photosensitization of the abnormal cells. This photosensitization can be achieved by the application 5-aminolaevulinic acid (5-ALA) or its derivatives. The key cellular principle is the preferential accumulation of photosensitizers in abnormal tumour cells, causing a cascade effect of radical oxygen species once illuminated The preferential accumulation of photodynamically active porphyrins in tumour lesions in comparison with healthy tissue may be due to various mechanisms Porphyrins produced after 5-ALA administration are seen more in rapidly proliferating cells, such as tumour cells. The net result is cell death by necrosis and apoptosis.Topical photodynamic therapy is practical and non-invasive and is particularly suited to dermatological indications. A variety of pre-malignant and malignant skin lesions including Bowen´s disease, actinic keratoses (AKs) and basal cell carcinoma (BCC) have been treated with success. The role of PDT in inflammatory dermatoses remains to be established.

To jest tylko fragment artykułu. Aby przeczytać całość, przejdź do Czytelni medycznej.