Hormonalna terapia zastępcza a skóra

Dorota Wojnowska, Maria Juszkiewicz-Borowiec, Grażyna Chodorowska, Dorota Czelej

Streszczenie
The skin appears to act as an end-organ target for estrogenic action. Marked structural and functional skin changes occurring after the menopause can be related to altered hormonal profile, especially reduced estrogen level. Postmenopausal estrogen deficiency may result in a wide physiologic disturbances, including vasomotor symptoms (hot flushes), mood changes, urogenital atrophy, an increase in the risk of osteoporosis and coronary heart disease. Estrogen loss at the menopause has a profound influence on skin. This report gives review of dermatologic problems of the menopause such as hormonal skin aging, anogenital lichen sclerosus, atrophic vulvovaginitis, dysaesthetic vulvodynia, stomatodynia, climacteric keratoderma or hair loss. Numerous studies suggest that hormone replacement therapy, especially estrogens increase collagen and water content, dermal thickness and elasticity, and improve the quality of epidermis. Also topical use of progesterone or estrogen compounds was found to diminish skin aging symptoms. Although hormonal skin aging is no indication for hormone replacement therapy the beneficial influence on skin parameters is a positive side effect of such treatment of menopause.

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